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First, Sensing and Destruction: COFs, equipped with precisely integrated sensitizing units, efficiently respond to external stimuli (e.g., light, ultrasound, radiation) or endogenous triggers (e.g., H 2 O 2 ), generating intense local biochemical effects such as bursts of ROS, hyperthermia, or DNA damage ( Figure 2 ) (155, 156, 166)

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PMID: Summary Keywords acute pancreatitis, inter-organellar interactions, mitochondria, mitochondria-associated membranes, pancreatic acinar cells Citation Chooklin S and Chuklin S (2026) Tangled contacts: mitochondrial interactions with cellular organelles in acute pancreatitis