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Thus, it is recommended to investigate for this AE in SGLT2i-treated patients with symptoms of ketoacidosis, such as nausea, vomiting, abdominal pain, ketonuria, and/or ketonemia, regardless of the current glucose status [74]

It stimulates L-cells in the lower intestine and colon, encouraging your body to produce more natural GLP-1

Topline results from the Phase 1 trial include: Observed dose-linear pharmacokinetics with a half-life of 380 hours, consistent from subject-to-subject, based on the ultra-long clearance conferred by HALO, Metseras proprietary, novel peptide lipidation platform technology

The dual agonism also explains why tirzepatide produces different side effect profiles than semaglutide and other pure GLP-1 agonists