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In this model we exposed BALB/c mice to Alternaria alternata and treated them with melatonin both at 17:00, since this is a time point that has been found to result in the most severe induction of features of allergic airway pathology (42)

However, the interquartile ranges were significantly smaller for DIA compared to DDA and generally dropped at the higher loads (2:1) compared to the more dilute sample (0.25:1)

By enhancing SIRT6 activity, fucoidans improve DNA repair mechanisms and reduce tissue senescence, particularly in the kidney and lung, thereby extending healthspan in aged mice 192,193