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GLP-1 Analogue liraglutide attenuates mutant huntingtin-induced neurotoxicity by restoration of neuronal insulin signaling

Liu J, Song L, Liu S, Zhao S, Jiang Q, Ding B

The significant weight-loss effectiveness of the MK-801-GLP-1 conjugate, as well as the potent hypothalamic alterations in proteins and transcripts associated with NMDA receptor-related neuroplasticity, indicate that the changes in the compounds biodistribution driven by glucagon-like peptide-1-regulated targeting might effectively bypass MK-801 delivery to vagal afferents and targeted neuronal cells within the nucleus of tractus solitarius (NTS)

I started to notice immediate effect on my hunger and cravings, and it took about six weeks before I started to really notice a change in how my body looked in the mirror