On the basis of several putative modes of action under investigation (for example, neuroprotective and anti-inflammatory properties, regulation of reward pathways), there is an emerging consensus that GLP-1RAs could be repurposed for use in neuropsychiatric conditions 25,26,27,28,29,30,31,32
Natural GLP-1 is easily degraded by enzymes with a short half-life of only 2-5 minutes, making it unavailable for direct therapeutic use
HTA Health Technology Assessment, a structured evaluation of the clinical and economic value of health technologies such as drugs and diagnostics
References Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, et al