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Table 8: Effect of Coadministered Drugs on Rosuvastatin Systemic Exposure Table 9: Effect of Rosuvastatin Coadministration on Systemic Exposure to Other Drugs EE = ethinyl estradiol, NG = norgestrel, QD= Once daily 1 Clinically significant pharmacodynamic effects [see Drug Interactions (7.3)] 2 Mean ratio with 90% CI (with/without coadministered drug, e.g., 1= no change, 0.7=30% decrease, 11=11-fold increase in exposure) Disposition of rosuvastatin, involves OATP1B1 and other transporter proteins

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Homo-Delarche F, Calderari S, Irminger JC, Gangnerau MN, Coulaud J, Rickenbach K, et al

chronic or excessive use poses greater depletion risk