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Get the details in the Concerns and Cautions section of our Joint Supplements Review

Tirzepatide is also designed to interact with GIP receptors, which may play a role in how the body processes nutrients

It binds the GHRH receptor (GHRHR) on pituitary somatotrophs, activating adenylyl cyclase via a Gs-protein, which raises intracellular cAMP and promotes GH secretion and somatotroph proliferation over time [3]

The further synergistic combination approach with other gastrointestinal hormones and creation of dual GIP/GLP-1 receptor agonists, such as tirzepatide and GLP-1/GIP/glucagon receptor triagonist, retatrutide, has shown unprecedented pharmacologically achieved weight loss with further cardiometabolic benefits in both obesity and T2DM