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When the body has difficulty breaking down histamine, it can lead to a variety of symptoms, including: Head: Headaches or migraines, dizziness, lightheadedness Skin: Flushing, skin rashes (like hives), itchy skin or eyes Respiratory: Nasal congestion, runny nose, asthma-like symptoms (wheezing, shortness of breath) Gastrointestinal: Bloating, diarrhea, nausea, digestive issues Heart: Low blood pressure, palpitations Other: Anxiety, irritability, fatigue, sleep disturbances or insomnia Salicylate Intolerance Salicylates are naturally occurring chemicals found in many fruits, vegetables, herbs, spices, processed foods, as well as certain medications and topical products

Semaglutide has been associated with early worsening of diabetic retinopathy in clinical trials, particularly in patients with pre-existing retinopathy and rapid improvement in glycaemic control

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3.2.3 Cytosolic mtDNA and the cGAS-STING pathway mtDNA is particularly vulnerable to oxidative damage due to its lack of histone protection and proximity to ROS generation sites (Wang et al., 2025a