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Where the research should go next Key open questions include how much endogenous GLP1 increase is needed for sustained weight change, whether combinations of diet, prebiotics, probiotics and nutraceuticals can match injectable outcomes, and the longterm safety of such combinations

The most well-studied pathways associated with cellular senescence are the p53/p21 CIP1 and/or p16INK4A/Rb tumor suppressor pathways

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Most available evidence does not distinguish between the major types of diabetes mellitus and is related to type 2 diabetes mellitus owing to its high prevalence