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Clinical trials have demonstrated that nausea, diarrhea, vomiting, constipation, and abdominal discomfort occur frequently, particularly during dose initiation and escalation

Diabetic patients have reported experiencing worsening blood sugar spikes and higher blood sugar levels than before they started taking the drug

[6] These delicate threads contain unique compounds including safranal, crocin, and picrocrocin - natural molecules that research suggests can influence our relationship with food

Prior studies have produced mixed results, with some reporting elevated risk and others finding weaker or null associations. Variations in study design, patient populations, follow-up duration and analytic methods likely contribute to these discrepancies