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Rate constants for mammalian glutaredoxins and poplar GrxS12 range from 2.5 10 4 to 2 10 6 M 1 s 1 and also support a rate-limiting reductive half-reaction 19,20,21,37

However, randomized controlled trials reported comparable dementia risk across treatments, likely due to limited follow-up duration and smaller cognitive outcome datasets 89

The most common side effects are gastrointestinal including nausea, vomiting, and diarrhoea and are most pronounced during dose increases

This medication is also effective in relieving pain, specifically postherpetic neuralgia (pain that follows shingles) and diabetic neuropathy