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Free radicals come from normal body processes, but they also increase because of: Poor sleep Stress Alcohol and smoking Illness Medication side effects Poor nutrition Environmental pollutants When oxidative stress rises, your body must work harder to protect and repair itself

At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance

J Neural Transm 121:12691272 Liu D, Ke Z, Luo J (2017) Thiamine deficiency and neurodegeneration: the interplay among oxidative stress, endoplasmic reticulum stress, and autophagy

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