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The gut microbiota-derived Pathogen-Associated Molecular Patterns, including LPS and peptidoglycan, are recognized by Pattern Recognition Receptors (PRRs), in particular Toll-like receptors and NOD-like receptors, which are expressed on osteoclasts and osteoblasts (236)
The combined effect can significantly increase the risk of severe gastrointestinal side effects, including nausea, vomiting, and diarrhea
It could also cause people to choose lower-fat, less energy-dense foods
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