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When someone carries a heterozygous mutation, they usually have one functional copy and one altered copy

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A "thrifty" genotype was defined as "being efficient in the intake and/or utilization of food." Thus, during famines, individuals with a "thrifty" genotype would have a survival advantage because they relied on larger, previously stored energy to maintain homeostasis, whereas those without "thrifty" genotypes would be at a disadvantage and less likely to survive (4)