Understanding your genetic predisposition to GLP-1 sensitivity can help your provider fine-tune your starting dose or protocol to minimize diarrhea risk from the beginning
Insurance companies such as United Healthcare, Cigna, and Blue Cross Blue Shield have specific coverage protocols often requiring prior authorization, particularly for those with a BMI of 30 or higher or 27 or higher with related weight conditions
Michele Green has been expertly treating patients in her Upper East Side, New York City, office for more than 25 years
Very common (10% of patients) Nausea peaks during titration, typically subsides within 48 weeks at a stable dose Vomiting, diarrhoea, constipation Abdominal pain or discomfort Reduced appetite (this is the therapeutic effect, not an adverse effect) Less common but serious stop and see a doctor Severe, persistent abdominal pain radiating to the back possible pancreatitis Right upper abdomen pain, fever, yellowing possible gallstones / gallbladder disease Persistent neck lump, hoarseness, difficulty swallowing evaluate thyroid Rapid heartbeat, severe dehydration from vomiting Hypoglycaemia when semaglutide is combined with insulin or sulfonylureas What the Indian data shows: a 2025 study of Indian patients found GI side effects are the leading cause of discontinuation, peaking during dose escalation