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The Lancet just answered that question and the results are worth discussing
Furthermore, the activation of GLP-1R signaling in the ventromedial hypothalamus (VMH) can also control energy expenditure by promoting food intake-independent weight loss by inducing brown adipose tissue (BAT) thermogenesis and browning through a sympathetic drive to BAT [6]
It covers what you should do to lower the chance of side effects, as outlined in the patient information leaflet
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