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GLP-1 Receptors Exist Throughout the Body Although GLP-1 medications work in the pancreas to regulate insulin and glucagon, GLP-1 receptors are widely distributed in other areas of the body, including the brain, cardiovascular system, immune system, gut, and kidneys, says Diana Isaacs, PharmD, CDCES, an endocrine clinical pharmacy specialist in the Endocrine and Metabolism Institute at Cleveland Clinic in Ohio

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Weight loss typically becomes measurable between day 10 and day 21, with initial losses of 1-3 pounds depending on starting weight, baseline calorie intake, and metabolic factors

Although physiological levels of GLP-1 can improve glycemic control, pharmacological levels of GLP-1 must be reached to promote weight loss