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The proportion of patients in each duration category varied in both trials

Some large database analyses have suggested a modest increase in pancreatitis risk, particularly in the first few months after initiation, while others have found no association after adjusting for confounding factors such as obesity, gallbladder disease, and alcohol use

Weight loss is a significant consideration for both medications, especially given the obesity epidemic and its association with conditions like Type 2 Diabetes

JG is supported by the Wellcome Trust Leicestershire Healthcare Inequalities Improvement Doctoral Training Programme (223512/Z/21/Z)