Cyanocobalamin is indicated for Vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug/Laboratory Test Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
In tendon-cell work, the peptide has been associated with upregulation of the growth-hormone receptor on fibroblasts, potentially sensitizing healing tissue to circulating growth signals
What the Research Says Today Modern research has shown that the "destruction" of B12 by Vitamin C is likely not a significant issue for most people at normal doses
One twist runs the other way: growing research, including early trials, shows these drugs cut cravings, so many want less