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In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF

This reaction is catalyzed by mitochondrial 1-hydroxylase (CYP27B1), producing 1,25-dihydroxyVitamin D [1,25(OH)D], the biologically active form of Vitamin D [94, 95]

The implementation of a combination of biomarker tests, that includes imaging measures of BBB dysfunction, could aid in early diagnosis, in monitoring disease progression and in evaluating treatment response to new drugs (Vellas, 2021)