Other gene therapies for medical conditions have shown a risk for this and other toxic side effects
The natural fermentation of dairy products has been recorded as far back as 10,000 BC
However, although commonly reported by patients, these symptoms are mostly mild, are rarely a reason for discontinuation of therapy, and seem to decrease over time with ongoing treatment.7,25e27 Although gastrointestinal side-effects occurred commonly in the large cardiovascular outcome trials, most were reported in the first weeks after initiation and they only led to discontinuation of treatment in 1e3% of cases.10,11 On the ICU, GLP-1 was also found to decrease gastric motility, although its effect was minimal when gastric emptying was already delayed.28 In patients with diabetes mellitus, gastroparesis is a known complication that requires attention and appropriate action by anaesthesiologists
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