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According to the FDA, BPC-157 may pose a risk for immunogenicity when combined with compounded medications

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Specifically increasing GABAergic inhibition and reducing glutamatergic excitation

This has been documented in human clinical trials, in which people taking ME-3 orally for several weeks exhibit a 26% increase in total antioxidant activity. In summary, Lactobacillus fermentum ME-3 has been shown to have the highest Total Antioxidant Activity (TAA) and the highest Total Antioxidant Status (TAS) of any probiotic tested to date. 3) Supports cardiovascular health: Lactobacillus fermentum ME-3 has been shown to lower triglycerides and increase levels of the good HDL-cholesterol