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Critically, the benefit appeared to be only partially explained by weight loss alone, suggesting direct cardioprotective effects through GLP-1 receptor signaling in the heart and vasculature

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In summary, the composition of BAs in T2DM patients requires further analysis through additional clinical studies that consider relevant factors such as age, sex, geographic location, the use of bile acid drugs (e.g., metformin), and metabolic surgery [19, 35, 36]

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