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Effect of short-term high calorie and/or high-fat diet in inducing insulin resistance The literature consistently reports that short-term HC, HC with high-fat (HCHF) or HFD impair insulin action as measured by glucose tolerance tests, mixed meal challenges or hyperinsulinemiceuglycemic clamp (Table 2), confirming that high-fat and/or HC diets are a suitable model to study diet-induced insulin resistance