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Change in Blood Pressure as Function of Weight-Change Quartile at 82 Weeks Adding Exenatide to Glucose-Lowering regimen reduces heart failure risk 50,330 patients taking exenatide with insulin and another antidiabetic treatment were 57% less likely to develop heart failure compared to those that took insulin, antidiabetic treatment, but no exenatide (OR 0.43

Healthcare providers can assess whether symptoms represent normal adjustment to semaglutide or indicate a need for dose modification, temporary discontinuation, or investigation for alternative diagnoses

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Most are manageable, especially when treatment starts at a low dose and builds up gradually