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Furthermore, some were these drugs were associated with potential undesirable effects, such as the risk of heart failure or fractures (complications that are especially prevalent in patients with CKD), this is the case of thiazolidinediones, and the use of sulfonylureas and insulin are associated with weight gain or the risk of hypoglycemia

GLP-3, a novel triple agonist of the GIP, GLP-1, and GCG receptors, has demonstrated significant hepatoprotective effects in research involving individuals with MASLD

Figure 4 PD is the second-most common progressive neurodegenerative disease caused by degeneration of dopaminergic neurons in the substantia nigra (Al-Kuraishy et al., 2023c)

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