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90 KamimotoM.MizunoS.NakamuraT

Jenkins WM, Papapanou PN

Older adults (over 60 years) frequently develop B12 deficiency due to reduced gastric acid production (achlorhydria or hypochlorhydria), which impairs the release of B12 from food proteins

As well as from poor diet and digestion, vitamin B12 deficiencies can also be affected by a genetic condition such as: o Pernicious anaemia o Crohns disease o Treatment with proton-pump inhibitors o Atrophic gastritis o Coeliac disease o Use of antacids (acid is required to release B12 from food) o Gastrointestinal surgery o Use of certain medications o Use of illegal drugs and substances including nitrous oxide