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Noom, an online weight loss company, is unveiling its Microdose GLP-1 Rx Program, a service intended to limit side effects via personalized microdoses of GLP-1s, when clinically appropriate of course

Dietary approaches produce much more modest effects than prescription GLP-1 medications

A baseline physical examination should include: Resting heart rate and blood pressure (sitting and standing) Cardiac auscultation to detect murmurs or irregular rhythms Assessment for signs of heart failure (peripheral edema, jugular venous distension) Baseline electrocardiogram (ECG) should be considered for patients with known cardiovascular disease, cardiac symptoms, or history of arrhythmias, rather than routinely for all patients over a certain age

GLP-1 medicines in kidney and liver inflammation Treatment with an exenatide analog was found to significantly decrease hepatic lipid accumulation, liver weight, and plasma levels of alanine transaminase in mice on a high-trans-fat diet