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Individuals with central obesity, insulin resistance, elevated triglycerides, low HDL cholesterol, and high blood pressure face dramatically elevated cardiovascular risk

The transition from daily injections to weekly dosage and, finally, to oral formulations has considerably enhanced the treatment environment

Therefore, although the study is interesting from a biological standpoint and may be useful for generating hypotheses or for future, more comprehensive predictive models, the results alone do not yet justify direct clinical application or the routine use of genetic testing to guide treatment

Any deviation from established storage and handling practices can compromise research integrity, making results difficult to reproduce or compare