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The GAG composition is altered, reducing hydration and resilience

Cell Mol Immunol (2011) 8:21325

5a), a pro-drug that combines sulphapyridine (an antibiotic) and 5-aminosalicylic (an anti-inflammatory agent) linked by an azo bridge, has huge therapeutic potential, but is, unfortunately, labile under physiological conditions (70% degradation by colonic bacteria via azo cleavage

Sowers MR, Crawford S, McConnell DS, Randolph JF Jr, Gold EB, Wilkin MK, Lasley B

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