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Dig Liver Dis 33:768777

Ex vivo retinal TUNEL staining for apoptotic cells showed elevated levels of TUNEL-positive RPE and photoreceptors near areas of atrophy, suggesting these cells fates are intertwined [36]

doi: 10.1016/j.redox.2021.102082 220 BatesJVijayakumarAGhoshalSMarchandBYiSKornyeyevDet al

In this study, histopathological examination of both right sides in two groups was of great value not only in confirming the type of melasma but also adding another objective tool in evaluation of treatment response in two groups, it demonstrated a decrease in melanin in basal cell layer in epidermal types and in melanin and melanophages in dermis in mixed types in H and E and MF stained sections after treatment compared with baseline