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However, emerging data and mechanistic plausibility suggest that certain populations may be at higher risk of suboptimal intake or depletion, particularly with prolonged therapy, rapid weight loss, restricted dietary variety or pre-existing marginal nutrient status

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As we still have to wait for a further, wider review of GLP-1 RAs, one could argue that the guideline still feels behind the times in some areas, and that an opportunity is being missed for a potentially useful class of drugs.