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While the science is promising, most evidence comes from small-scale or preclinical studies rather than large clinical trials

Indeed, a 2019 literature review discussed berberines potential for antitumor effects against a few types of cancer, and a more recent review from 2024 highlighted its ability to support chemotherapy.13 49 At this time, the most extensive research on berberine has revolved around its impacts not on cancer but on diabetes and cholesterol management, so those are the health concerns for which the supplement is most likely to yield benefits

In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself