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In M1-type microglia, increased pentose phosphate pathway activity and aerobic glycolysis are associated with excessive production of ROS

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High blood pressure is one of the most common consequences of ADPKD, and about half of individuals with ADPKD develop end-stage kidney disease by age 60 (NHGRI 2013)

Overall, the antinutritional compounds in amaranth are within safe ranges and can be modulated by processing, allowing their bioactive benefits to be preserved without compromising nutrient bioavailability