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Even so, the chance of it happening is still very, very rare
Dysfunction in the gut barrier (intestinal hyperpermeability or leaky gut) appears in most autoimmune conditions, potentially serving as both a trigger for initial autoimmune development and a perpetuating factor that maintains immune dysregulation
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Furthermore, intestinal I/R injury can activate the vagus nerve, transmitting signals to the brain that influence neuronal activity and cognitive function, and alter gut microbial metabolite production, such as short-chain fatty acids (SCFAs), thus affecting neuronal signaling and cognitive processes (Wu et al., 2021
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