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In patients with ASCVD and BMI 30 kg/m, evolocumab was associated with a greater reduction in major adverse cardiovascular events, with a more favorable NNT compared with normal-weight individuals

The STEP UP trial showed that increasing the dose from 2.4 mg to 7.2 mg resulted in an additional 3% body weight loss

No para consumo humano

Therefore, the observed decrease in energy expenditure in our study is likely attributable not only to reduced food intake but also to reduced locomotor activity induced by GLP-1 analogs

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