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IMMUNOMODULATING AND IMMUNOSUPPRESSIVE DRUGS Calcineurin inhibitors (CIn) Cyclosporin A (CsA) and tacrolimus (TkL) hare used to treat autoimmune diseases and organ transplant patients

(4)L-proline is an amino acid that has been found to be protective against oxidative stress in various diseases, including heart disease

Phosphorylated eIF2 inhibits the translation of messenger RNA into protein, thereby reducing protein translation during ER stress (Harding et al., 1999)

Lysates were boiled at 95 C for 5 min, 20 g of total protein were subjected to separation by a 10% SDS gel, transferred onto nitrocellulose membranes (Amersham Biosciences) and blocked with 5% milk powder in PBS Tween (0.1%) for 1 h