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According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), the most frequent side effects include: Nausea very common, often most pronounced when starting treatment or increasing the dose Diarrhoea very common, can range from mild to moderate in severity Vomiting very common, may occur particularly during dose escalation Constipation very common, affects a significant proportion of patients Abdominal pain or discomfort common, typically transient Decreased appetite very common, related to the medication's mechanism of action These gastrointestinal symptoms are usually mild to moderate and tend to improve over time as the body adjusts to the medication

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Table 1 : Summary of SURPASS trials Effect on weight loss Currently the weight loss observed with semaglutide is greater than that reported for other approved anti-obesity medications

Individuals who already receive GLP-1 medications through their existing Medicare prescription drug coverage or are eligible for separate Medicare GLP-1 coverage, Medicare Part D, are excluded