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These reagents support two clinically relevant concepts: (1) Combination sensitization: FSP1 blockade can sensitize tumors to upstream ferroptosis-inducing nodes (for example, GPX4 inhibition or cystine import disruption), consistent with the idea that tumors rely on redundant antioxidant systems

While antioxidant defenses of the body are robust, factors like lifestyle, diet, and environmental exposures significantly influence the balance between free radical production and antioxidant capacity