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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

This anti-inflammatory action decreases oxidative stress across multiple organ systems, supporting its use in experimental protocols for chronic inflammation and metabolic disorders

5 Karg E, Odh G, Wittbjer A, Rosengren E, Rorsman H