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doi: 10.3389/fendo.2023.1271521 Received 02 August 2023 Accepted 17 November 2023 Published 30 November 2023 Volume 14 - 2023 Edited by Ashu Johri, Independent Researcher, New York, NY, United States Reviewed by Shubhadeep Roychoudhury, Assam University, India

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Regarding receptor-specific interactions, the retatrutideGLP-1R complex displays three salt bridges (D9 P R 7.35b , D15 P R299 ECL2 and K17 P E 1.33b ), with the first two also present in the retatrutideGIPR complex, while the last one is absent in GIPR due to the positively charged R131 1.33b

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