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If reactions first appeared or significantly worsened at a specific dose level, discuss the following options with your healthcare provider: extended time at the current dose before escalating further, smaller escalation increments , pre-injection antihistamine protocol, or exploring whether the therapeutic goals can be achieved at a lower dose

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Compound heterozygous MTHFR gene variants (677T/1298C) characteristically exhibit hypomethylation (Ren et al., 2018)