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Those who with neuropathy present with a warm, swollen, red foot requires a thorough work up for possible charcot neuroarthropathy, nonweight bearing and urgent referral to a foot care specialist to prevent foot deformities and instability leading to ulcerations and amputations

Since oxidative stress and inflammation are closely associated with insulin resistance, it is conceivable that the AGE-RAGE system may play a role in pathogenesis of insulin resistance observed in PCOS [30], regardless of circulating glucose levels, weight and obesity

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