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Timeline variation depends on individual factors including baseline blood pressure, hydration status, and sensitivity to the medication's cardiovascular effects

c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

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However, more research is needed as some studies show no association between vitamin E and this condition ( Like vitamin E, vitamin C is a powerful antioxidant that may protect your eyes against damaging free radicals ( Vitamin C and several other nutrients are used in the supplement AREDS, which may benefit those with AMD