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Following a stroke, chronic microglial activation and elevated levels of TNF occur in the brain, creating a disturbance of homeostasis that can perpetuate itself through an autocrine feed-forward loop

Gastroenterology 155 , 17201728 (2018)

Other challenges include treatment duration, inability to give medicine with food, inconvenient dosing schedules, administering multiple prescribed medications, perceived adverse effects causing pet owners to stop administering medication, and complex treatment plans (3, 1517)