Cardiovascular history : Patients with established cardiovascular disease may benefit from GLP-1 receptor agonists with proven cardiovascular benefits, such as semaglutide, dulaglutide, or liraglutide, which may influence medication selection and target dosing
The company has an internal once-weekly peptide (NNC-06620419, Phase 2 started October 2025), a ~$2B license on United Laboratories' UBT-251 (Phase 1b/2a running, 19.7% weight loss at 24 weeks in the Chinese Phase 2), a $2.2B collaboration with Septerna for small-molecule oral GPCR agonists including a triple, and a long-running in-house discovery pipeline
For patients on Retatrutide, I recommend exactly five supplements: whey protein (to hit protein targets), creatine monohydrate (strength preservation), electrolyte powder (hydration), vitamin D (bone health), and omega-3s (inflammation)
Minimum side effect disruption