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Researchers have documented the safety profile observed in published Phase 2 research as predominantly gastrointestinal effects (nausea, diarrhoea, vomiting) typical of the incretin class, occurring most prominently during dose escalation and tending to decline with continued exposure (PMID 39515565, PMID 41785010)

The results showed that early administration of metformin was associated with a significant increase in height in 15-year-old children (Ibanez et al., 2011)

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A consistent downward trend of 0.5 to 1.5 percent of body weight per week while on a therapeutic dose is a typical range