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JTF may protect cartilage by inhibiting ferroptosis and aquaporin dysregulation driven by NCOA4-HMGB1

However, if the interruption exceeded two weeks , many clinicians recommend restarting at a lower dose (usually 0.25 mg weekly) and gradually re-titrating upwards according to the licensed schedule (0.25 mg 0.5 mg 1 mg, and potentially to 2 mg for type 2 diabetes) over 48 weeks to reduce gastrointestinal side effects

1 Large epidemiological studies report a prevalence of MASLD of up to 79% among individuals with both T2DM and obesity

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