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BBB penetration is facilitated by the compound's lipophilicity and small size, though the exact mechanism of CNS entry (passive diffusion vs
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For weight loss, it appears to reduce appetite and increase the feeling of satiety (fullness)
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[11] [12] Prescribers should check the relevant SmPC for hepatic guidance for each agent Use in pregnancy and breastfeeding : DPP-4 inhibitors are not recommended during pregnancy or breastfeeding, as data on safety in these situations are limited
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