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Why GLP-1Related Muscle Loss Is Adaptive Remodeling Not Muscle Wasting All effective weight-loss interventionsdietary, surgical, exercise-based, or pharmacologicreduce both fat and lean tissue to some degree

GLP-1 and PYY3-36 as complementary gut hormones in the regulation of appetite and energy balance

However, glucagon signaling also increases energy expenditure, promotes lipid oxidation, and may reduce hepatic fat content

Some research suggests that weight loss itself regardless of the method can improve testosterone levels in men with obesity and restore menstrual regularity in women with polycystic ovary syndrome (PCOS) (see NICE NG227: Polycystic ovary syndrome diagnosis and management), both of which may positively influence libido